A chemist working for a pharmaceutical company claimed four criteria for extraordinary ability. The AAO affirmed the director's finding on judging and scholarly articles but rejected original contributions, finding employer statements about trade secrets and potential drug discoveries lacked evidence of major field impact.

A data scientist sought EB-1A extraordinary ability classification. The AAO dismissed because he satisfied only two of three required evidentiary criteria. His original contributions claim failed; publication venue prestige, citation counts, and high percentile rankings did not demonstrate major significance or influence in the field.

Researcher in gastroenterology sought EB-1A extraordinary ability. Director initially found only two criteria met, but AAO considered three criteria in final merits determination. AAO found petitioner failed all analyzed criteria and did not demonstrate sustained national or international acclaim required for classification.

An epigenetics and oncology researcher filed I-140 for extraordinary ability. He satisfied three initial criteria including original contributions of major significance. However, AAO reversed on final merits, finding productive career but insufficient sustained acclaim or evidence of very top of field status.