Dental care entrepreneur seeking NIW to establish dental practice. Claimed national importance based on dental professional shortage and environmental benefits of practice. AAO affirmed denial, finding that serving individual patients lacks national importance; professional shortage alone insufficient under Dhanasar framework.

A biomedical scientist and biotechnology executive with experience in molecular biology and clinical diagnostics proposed to establish a venture consulting practice for early-stage biotech companies. The AAO dismissed the appeal because the petitioner failed to demonstrate the proposed endeavor's national importance; the record showed only individualized client services without broader field-wide impact.

Franchise and business management consultant sought NIW to work as entrepreneur providing consulting services. AAO held petition failed because proposed endeavor lacked demonstrated national importance; generalized economic benefits and small business support insufficient without evidence of broader field impact or substantial economic effects.

A chemical engineer sought EB-2 classification with national interest waiver. The AAO found the petitioner did not establish eligibility for the underlying EB-2 advanced degree or exceptional ability classification because the record lacked evidence of requisite academic credentials and progressive employment experience, making the waiver issue moot.