Postdoctoral researcher in biomedical science seeking EB-1A extraordinary ability. Met judging and scholarly articles criteria but failed original contributions criterion. AAO dismissed appeal, finding insufficient evidence that research impact rises to major significance level required for extraordinary ability classification.

A chemist working for a pharmaceutical company claimed four criteria for extraordinary ability. The AAO affirmed the director's finding on judging and scholarly articles but rejected original contributions, finding employer statements about trade secrets and potential drug discoveries lacked evidence of major field impact.

Research associate in cellular and molecular carcinogenesis mechanisms claimed three criteria: judging, scholarly articles, and original contributions. AAO affirmed judging and scholarly articles met but reversed original contributions finding. On final merits, sustained national or international acclaim insufficient to demonstrate extraordinary ability.

A postdoctoral research scientist in regenerative medicine sought EB-1A classification. The AAO dismissed because she met only one of three required criteria: judging lacked specificity and original contributions lacked evidence of major significance to the overall field.