Pharmacist and entrepreneur sought NIW to operate business providing parenteral nutrition products. AAO affirmed denial, finding petitioner failed to describe proposed endeavor with sufficient specificity and provide corroborating evidence that business activities would achieve substantial national economic impact.

Dentist sought EB-2 advanced degree classification and NIW for dental support organization services. AAO affirmed denial because proposed endeavor lacked national importance; evidence showed only local clinic impact, not broader field or economic implications required by Dhanasar.

Oil and gas project manager with advanced degree seeks NIW. Director found substantial merit but not national importance. AAO affirmed that proposed endeavor lacks necessary prospective impact, broader field implications, or significant U.S. job creation or economic effects at national level.

A commercial airline pilot and captain with advanced qualifications proposed pilot and flight instructor work and aviation safety consultancy. The AAO held his expertise and prior success, while relevant to positioning under the second prong, do not establish national importance of the specific proposed endeavor, which lacks demonstrated broader implications for the aviation industry.