Applied and computational mathematician self-petitioned for EB-2 NIW to research guaranteed algorithms for large-scale systems, claiming prospective applications in cancer research, energy, and artificial intelligence. The AAO dismissed the appeal, finding substantial merit but insufficient evidence of national importance because the connection between the proposed research and asserted national-level impacts was too attenuated.

Medical device manufacturing entrepreneur with advanced degree sought NIW. Petitioner established qualifying advanced degree status but failed first Dhanasar prong by not demonstrating specific endeavor has national importance. Appeal dismissed without reaching well-positioned or balance prongs.

A statistician with an approved labor certification sought a national interest waiver to develop statistical methods for biomedical discovery and clinical trials. The AAO dismissed the appeal, holding expert letters lacked persuasive corroborating evidence that his specific proposed endeavor would achieve national importance in biomedical science.

Software developer seeks NIW claiming field importance. AAO agreed petitioner failed to identify specific endeavor or demonstrate national importance; general assertions about software development do not establish impact beyond employer or customer base.