Mental health hospital petitions for EB-2 NIW on behalf of rehabilitation therapist providing art therapy to forensically committed patients. Beneficiary qualifies as advanced degree professional but proposed endeavor lacks national importance; job duties would not impact therapeutic field broadly at national level.

A statistics researcher proposing to develop predictive models for cybersecurity and data analysis sought NIW. The AAO dismissed the appeal, finding the specific proposed endeavor lacked national importance under Dhanasar's first prong, as it would not impact the field broadly.

An employer petitioned for NIW for study management associate II overseeing oncology and hematology clinical trials for advanced therapies. AAO affirmed denial: while the work was meritorious, petitioner failed to show the specific endeavor had national importance or substantial economic impact beyond the employer's clients and consumers.

A hospitalist sought a national interest waiver for EB-2 classification. The AAO held the proposed endeavor lacked national importance because it would not impact the field broadly or produce substantial prospective economic effects, despite serving an underserved area. First prong of Dhanasar test failed.