A nurse seeking EB-2 with national interest waiver to operate a home health care business. AAO held the specific endeavor lacks national importance under Dhanasar because evidence showed only industry importance, not the business's prospective broader impact or employment potential.

A cardiologist and director seeking NIW under EB-2 claimed substantial merit and national importance for clinical work, teaching, and leadership. AAO found substantial merit but not national importance; clinical impact limited to individual workplace. Petitioner also failed to demonstrate being well positioned to advance endeavor.

Physical therapist assistant sought EB-2 exceptional ability classification and NIW. Director approved exceptional ability; AAO withdrew that finding and found petitioner did not qualify for underlying EB-2 classification due to insufficient evidence of degree equivalency and continuous professional licensure, rendering NIW analysis unnecessary.

A home health services company owner sought EB-2 NIW classification as an advanced degree professional. The petitioner proposed operating a home health company aligned with federal healthcare initiatives. The AAO held that substantial merit in the field does not establish national importance; the specific endeavor must demonstrate broader implications or meaningful industry impact beyond serving prospective patients.