A machine learning scientist with a U.S. PhD in computational biosciences sought EB-2 NIW classification for developing bioinformatics algorithms and predictive models for disease detection and precision medicine. The AAO affirmed denial, finding the endeavor had substantial merit but lacked national importance and the petitioner was not well positioned to advance it without demonstrating broader impact or employer approval for external research dissemination.

An entomology professor with a Ph.D. in medical entomology seeks an EB-2 national interest waiver for research on German cockroach insecticide resistance. AAO held the proposed endeavor lacks the specific detail, novelty, and documented potential for broad impact required to establish national importance under Dhanasar's first prong.

Electrical engineer and medical imaging researcher with Ph.D. in ultrasound diagnostic analysis sought EB-2 with national interest waiver. Claimed research has broad field implications. AAO sustained, finding all three Dhanasar prongs met: substantial merit and national importance demonstrated, well-positioned given Ph.D. and track record, and U.S. balance favored waiver.

An expert in human capital formation with a doctoral degree sought EB-2 national interest waiver to operate a nonprofit advancing STEM education and gender equity. The AAO found substantial merit but no national importance; the work was limited to one Texas community college without broader field implications.