Applied and computational mathematician self-petitioned for EB-2 NIW to research guaranteed algorithms for large-scale systems, claiming prospective applications in cancer research, energy, and artificial intelligence. The AAO dismissed the appeal, finding substantial merit but insufficient evidence of national importance because the connection between the proposed research and asserted national-level impacts was too attenuated.

Computer scientist researching AI applications in healthcare sought EB-2 national interest waiver. Proposed work on multimodal AI systems addressing healthcare transparency. AAO found proposed endeavor had substantial merit and national importance with global implications, applicant well positioned via expertise and prior government-funded research, and waiver beneficial to U.S. on balance given national security and competitiveness implications.

Cybersecurity professional sought EB-2 NIW for proposed work developing advanced payment security and fraud detection systems. AAO found substantial merit but concluded endeavor lacked national importance; work would not extend beyond prospective employers or customers to impact field broadly or produce substantial economic benefits.

A business analyst sought EB-2 NIW to establish an AI cybersecurity business as CEO and software developer. The AAO dismissed the appeal, finding the proposed endeavor has substantial merit but lacks demonstrated national importance; alignment with government cybersecurity priorities does not establish the specific endeavor's national significance.