Dental care entrepreneur seeking NIW to establish dental practice. Claimed national importance based on dental professional shortage and environmental benefits of practice. AAO affirmed denial, finding that serving individual patients lacks national importance; professional shortage alone insufficient under Dhanasar framework.

Medical device manufacturing entrepreneur with advanced degree sought NIW. Petitioner established qualifying advanced degree status but failed first Dhanasar prong by not demonstrating specific endeavor has national importance. Appeal dismissed without reaching well-positioned or balance prongs.

Surgical technologist specialist sought EB-2 classification with national interest waiver. AAO found her proposed endeavor lacked substantial merit and national importance as required by Dhanasar; benefits were limited to specific patients and employer rather than advancing the field or nation broadly.

Technical project manager with Ph.D. equivalent sought NIW for EB-2. Proposed developing thermal management designs for data centers and electronics. Failed to demonstrate national importance; petitioner's planned role as employee rather than independent researcher reduced prospective impact. Appeal dismissed.