A chemist working for a pharmaceutical company claimed four criteria for extraordinary ability. The AAO affirmed the director's finding on judging and scholarly articles but rejected original contributions, finding employer statements about trade secrets and potential drug discoveries lacked evidence of major field impact.

Cardiovascular researcher met two criteria but needed three. Original contributions criterion failed: guidelines participation and citations lack specific evidence of major significance; reference letters too conclusory; prestigious journal publication alone insufficient. Record does not demonstrate sustained acclaim or top-tier status required for extraordinary ability.

Assistant professor of anesthesiology sought EB-1A extraordinary ability classification. Met judging criterion but failed three others. Published material did not qualify; original contributions, though evidenced by modest citations and presentations, lacked major significance; leading role unsupported; evidence did not demonstrate elite status. Appeal dismissed.

Postdoctoral researcher in biomedical science seeking EB-1A extraordinary ability. Met judging and scholarly articles criteria but failed original contributions criterion. AAO dismissed appeal, finding insufficient evidence that research impact rises to major significance level required for extraordinary ability classification.