Molecular biologist in computational biology claimed three criteria. AAO found petitioner met judging and scholarly articles criteria but not original contributions of major significance, as letters lacked evidence of realized or implemented contributions, and citations alone without field context do not establish major significance. With only two criteria met, appeal was dismissed.

Postdoctoral bioelectronics researcher sought EB-1A classification. AAO dismissed motion to reconsider prior appeal dismissal, affirming that record failed to establish major significance of contributions and did not meet the minimum three criteria threshold.

A chemist working for a pharmaceutical company claimed four criteria for extraordinary ability. The AAO affirmed the director's finding on judging and scholarly articles but rejected original contributions, finding employer statements about trade secrets and potential drug discoveries lacked evidence of major field impact.

An epigenetics and oncology researcher filed I-140 for extraordinary ability. He satisfied three initial criteria including original contributions of major significance. However, AAO reversed on final merits, finding productive career but insufficient sustained acclaim or evidence of very top of field status.