Cardiovascular researcher met two criteria but needed three. Original contributions criterion failed: guidelines participation and citations lack specific evidence of major significance; reference letters too conclusory; prestigious journal publication alone insufficient. Record does not demonstrate sustained acclaim or top-tier status required for extraordinary ability.

Clinical pharmacologist employed by biopharmaceutical company met three initial evidentiary criteria but lacked sustained national or international acclaim demonstrating placement among the very top of field in pharmacokinetics and pharmacodynamics; appeal dismissed on final merits.

A chemistry, manufacturing, and controls regulatory affairs researcher met three evidentiary criteria (published material, judging, scholarly articles). However, on final merits the AAO found insufficient evidence of sustained national acclaim or that she ranked among the very top of her field. Limited press coverage and peer review activities did not demonstrate differentiation from peers. Appeal dismissed.

A physician in diagnostic radiology residency seeks EB-1A extraordinary ability classification. The AAO dismissed the appeal, finding only two criteria met and concluding the beneficiary lacks the sustained national or international acclaim required for the small percentage at the very top of the field.